Sodium/Calcium Exchange: Its Physiological Implications

Sodium/calcium exchange: its physiological implications.

The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ pump. As a reversible transporter, it also mediates Ca2+ entry in parallel with various ion channels. The energy for net Ca2+ transport by the Na+/Ca2+ exchanger and its direction depend on the Na+, Ca2+, and K+ gradie...

WASP Family Proteins: Their Evolution and Its Physiological Implications

WASP family proteins control actin polymerization by activating the Arp2/3 complex. Several subfamilies exist, but their regulation and physiological roles are not well understood, nor is it even known if all subfamilies have been identified. Our extensive search reveals few novel WASP family proteins. The WASP, WASH, and SCAR/WAVE subfamilies are evolutionarily ancient, with WASH the most univ...

VDAC inhibition by tubulin and its physiological implications.

Regulation of mitochondrial outer membrane (MOM) permeability has dual importance: in normal metabolite and energy exchange between mitochondria and cytoplasm, and thus in control of respiration, and in apoptosis by release of apoptogenic factors into the cytosol. However, the mechanism of this regulation involving the voltage-dependent anion channel (VDAC), the major channel of MOM, remains co...

Key Exchange in 802.15.4 Networks and Its Performance Implications

Abstract. The IEEE 802.15.4 specification is a recent low data rate wireless personal area network standard. While basic security services are provided for, there is a lack of more advanced techniques which are indispensable in modern personal area network applications. In addition, performance implications of those services are not known. In this paper, we describe a secure data exchange proto...

The Intellectual Property Regime and its Implications for Knowledge Exchange